| 2024-04 |
Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential |
Frontiers in Pharmacology
|
| 2024-04 |
Improvement of NASH and liver fibrosis through modulation of the gut-liver axis by a novel intestinal FXR agonist |
Biomedicine & Pharmacotherapy
|
| 2024-02 |
Anticancer Evaluation of Novel Benzofuran–Indole Hybrids as Epidermal Growth Factor Receptor Inhibitors against Non-Small-Cell Lung Cancer Cells |
Pharmaceuticals
|
| 2023-11 |
Novel small molecule-mediated restoration of the surface expression and anion exchange activity of mutated pendrin causing Pendred syndrome and DFNB4 |
Biomedicine & Pharmacotherapy
|
| 2023-05 |
ANO1-downregulation induced by schisandrathera D: a novel therapeutic target for the treatment of prostate and oral cancers |
Frontiers in Pharmacology
|
| 2023-04 |
Overlooked KCNQ4 variants augment the risk of hearing loss |
Experimental & Molecular Medicine
|
| 2023-02 |
Pentacyclic triterpenoids saponins pannosides A-E from Tripolium pannonicum |
Frontiers in Marine Science
|
| 2023-01 |
Inhibition of ANO1 by Cis- and Trans-Resveratrol and Their Anticancer Activity in Human Prostate Cancer PC-3 Cells |
International Journal of Molecular Sciences
|
| 2023-01 |
Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5- a]pyrimidine CFTR Activator That Ameliorates Dry Eye Disease |
Journal of Medicinal Chemistry
|
| 2022-11 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1 |
International Journal of Molecular Sciences
|
| 2022-11 |
Synthesis and Biological Evaluation of a Fused Structure of Indolizine and Pyrrolo[1,2-c]pyrimidine: Identification of Its Potent Anticancer Activity against Liver Cancer Cells |
PHARMACEUTICALS
|
| 2022-11 |
The SLC26A9 inhibitor S9-A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion |
FASEB Journal
|
| 2022-11 |
Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin |
Acta Pharmacologica Sinica
|
| 2022-09 |
Anticancer effect of verteporfin on non-small cell lung cancer via downregulation of ANO1 |
Biomedicine and Pharmacotherapy
|
| 2022-09 |
GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP |
International Journal of Molecular Sciences
|
| 2022-09 |
Generation of a poly-functionalized indolizine scaffold and its anticancer activity in pancreatic cancer cells |
BIOORGANIC CHEMISTRY
|
| 2022-07 |
Amelioration of SARS-CoV-2 infection by ANO6 phospholipid scramblase inhibition |
CELL REPORTS
|
| 2022-05 |
In-vitro and in-vivo anti-allergic effects of magnolol on allergic rhinitis via inhibition of ORAI1 and ANO1 channels |
JOURNAL OF ETHNOPHARMACOLOGY
|
| 2022-05 |
VI-116, A Novel Potent Inhibitor of VRAC with Minimal Effect on ANO1 |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|
| 2022-05 |
Novel CFTR Activator Cact-3 Ameliorates Ocular Surface Dysfunctions in Scopolamine-Induced Dry Eye Mice |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|
| 2022-01 |
Oleanane-type triterpene saponins from Aralia armata leaves and their cytotoxic activity |
Natural Product Research
|
| 2022-01 |
PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways Are Essential for Thrombin-Induced Morphological Changes in MEG-01 Cells |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|
| 2021-11 |
Triterpenoid glycosides from the rhizomes of Allium ascalonicum and their anoctamin-1 inhibitory activity |
NATURAL PRODUCT RESEARCH
|
| 2021-11 |
Cinobufagin Exerts Anticancer Activity in Oral Squamous Cell Carcinoma Cells through Downregulation of ANO1 |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|
| 2021-10 |
Anti-Inflammatory Effect of Licochalcone A via Regulation of ORAI1 and K+ Channels in T-Lymphocytes |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|
| 2021-09 |
Chemical constituents from Schisandra sphenanthera and their cytotoxic activity |
NATURAL PRODUCT RESEARCH
|
| 2021-09 |
Novel positive allosteric modulator of protease-activated receptor 1 promotes skin wound healing in hairless mice |
BRITISH JOURNAL OF PHARMACOLOGY
|
| 2021-07 |
Diethylstilbestrol, a Novel ANO1 Inhibitor, Exerts an Anticancer Effect on Non-Small Cell Lung Cancer via Inhibition of ANO1 |
International Journal of Molecular Sciences
|
| 2021-06 |
Two new iridoid-sesquiterpene conjugates from Rehmannia glutinosa |
PHYTOCHEMISTRY LETTERS
|
| 2021-04 |
Isorhamnetin Ameliorates Dry Eye Disease via CFTR Activation in Mice |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|
| 2021-02 |
Chemical constituents from Schisandra perulata and their cytotoxic activity |
PHYTOCHEMISTRY LETTERS
|
| 2020-09 |
Novel ANO1 Inhibitor from Mallotus apelta Extract Exerts Anticancer Activity through Downregulation of ANO1 |
International Journal of Molecular Sciences
|
| 2020-09 |
Four new sucrose diesters of substituted truxinic acids from Trigonostemon haonbaensis with their anoctamin-1 inhibitory activity |
BIOORGANIC CHEMISTRY
|
| 2020-08 |
Inhibition of Pendrin by a small molecule reduces Lipopolysaccharide-induced acute Lung Injury |
THERANOSTICS
|
| 2020-08 |
Domino [4 + 2] Annulation Access to Quinone−Indolizine Hybrids: Anticancer N‑Fused Polycycles |
JOURNAL OF ORGANIC CHEMISTRY
|
| 2020-08 |
Diversity-oriented generation and biological evaluation of new chemical scaffolds bearing a 2,2-dimethyl-2H-chromene unit: Discovery of novel potent ANO1 inhibitors |
BIOORGANIC CHEMISTRY
|
| 2020-07 |
Luteolin reduces fluid hypersecretion by inhibiting TMEM16A in interleukin-4 treated Calu-3 airway epithelial cells |
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
|
| 2020-07 |
Punicalagin Ameliorates Lupus Nephritis via Inhibition of PAR2 |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|
| 2020-05 |
A domino annulation approach to 3,4-diacylpyrrolo[1,2-a]pyrazines: decoration of pyrazine units |
ORGANIC & BIOMOLECULAR CHEMISTRY
|
| 2020-04 |
Cytotoxic sesquiterpene glucosides from Fissistigma pallens |
PHYTOCHEMISTRY
|
| 2020-02 |
Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: synthesis and its anticancer activity in prostate cancer and breast cancer cells |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|
| 2019-11 |
Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma |
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
|
| 2019-10 |
Discovery of cycloartane-type triterpene saponins from Mussaenda glabra |
PHYTOCHEMISTRY LETTERS
|
| 2019-08 |
Rare KCNQ4 variants found in public databases underlie impaired channel activity that may contribute to hearing impairment |
EXPERIMENTAL AND MOLECULAR MEDICINE
|
| 2019-05 |
Chemical Constituents of Phoebe poilanei and Their Cytotoxic Activity |
NATURAL PRODUCT COMMUNICATIONS
|
| 2019-03 |
Quercetin 3-O-xyloside ameliorates acute pancreatitis in vitro via the reduction of ER stress and enhancement of apoptosis |
PHYTOMEDICINE
|
| 2018-12 |
Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|
| 2017-09 |
Synergistic mucus secretion by histamine and IL-4 through TMEM16A in airway epithelium |
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
|
| 2017-07 |
A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations |
NATURE CHEMISTRY
|
| 2017-03 |
Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells |
PLOS ONE
|
| 2016-12 |
Generation of Delta F508-CFTR T84 cell lines by CRISPR/Cas9-mediated genome editing |
BIOTECHNOLOGY LETTERS
|
| 2016-11 |
Enzyme-Responsive Procarriers Capable of Transporting Chloride Ions across Lipid and Cellular Membranes |
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
|
| 2016-05 |
Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2 |
PLOS ONE
|
| 2016-02 |
Potentiation of ΔF508- and G551D-CFTR Mediated Cl- Current by Novel Hydroxypyrazolines |
PLOS ONE
|
| 2015-10 |
Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP |
MOLECULAR PHARMACOLOGY
|
| 2015-08 |
Thick airway surface liquid volume and weak mucin expression in pendrin-deficient human airway epithelia |
Physiological reports
|
| 2015-07 |
Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines |
PLOS ONE
|
| 2015-06 |
Synthetic aminopyrrolic receptors have apoptosis inducing activity |
CHEMICAL SCIENCE
|
| 2014-12 |
Azobenzene-based chloride transporters with light-controllable activities |
CHEMICAL COMMUNICATIONS
|
| 2014-10 |
Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells (vol 6, pg 885, 2014) |
NATURE CHEMISTRY
|
| 2014-08 |
Imidazole-based small molecules that promote neurogenesis in pluripotent cells |
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
|
| 2014-07 |
Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice |
GUT
|
| 2014-04 |
Shank2 mutant mice display a hypersecretory response to cholera toxin |
JOURNAL OF PHYSIOLOGY-LONDON
|
| 2014-04 |
Developmental Changes of ENaC Expression and Function in the Inner Ear of Pendrin Knock-Out Mice as a Perspective on the Development of Endolymphatic Hydrops |
PLOS ONE
|
| 2014-02 |
Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia |
FASEB JOURNAL
|
| 2013-11 |
A Comparison of Ypet and Firefly Luciferase as Reporter Proteins for High-Throughput Screening |
Bioscience, Biotechnology and Biochemistry
|
| 2013-10 |
Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compounds |
Lab on a Chip
|
| 2013-09 |
Novel Amino-Carbonitrile-Pyrazole Identified in a Small Molecule Screen Activates Wild-Type and Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator in the Absence of a cAMP Agonist |
MOLECULAR PHARMACOLOGY
|
| 2012-07 |
Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors |
BIOORGANIC & MEDICINAL CHEMISTRY
|
| 2012-05 |
Fractionation of a herbal antidiarrheal medicine reveals Eugenol as an inhibitor of Ca 2+-activated Cl - channel TMEM16A |
PLOS ONE
|
| 2011-11 |
Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction |
FASEB JOURNAL
|
| 2011-01 |
TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells |
JOURNAL OF BIOLOGICAL CHEMISTRY
|
| 2010-11 |
Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea |
Faseb Journal
|
| 2010-08 |
CFTR-Adenylyl Cyclase I Association Responsible for UTP Activation of CFTR in Well-Differentiated Primary Human Bronchial Cell Cultures |
Molecular Biology of the Cell
|
| 2010-08 |
Dynamic Regulation of CFTR Bicarbonate Permeability by [Cl-](i) and Its Role in Pancreatic Bicarbonate Secretion |
Gastroenterology
|
| 2010-01 |
Crofelemer, an Antisecretory Antidiarrheal Proanthocyanidin Oligomer Extracted from Croton lechleri, Targets Two Distinct Intestinal Chloride Channels |
Molecular Pharmacology
|
| 2009-12 |
Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function |
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
|
| 2009-10 |
Nanomolar Potency Pyrimido-pyrrolo-quinoxatinedione CFTR Inhibitor Reduces Cyst Size in a Polycystic Kidney Disease Model |
Journal Of Medicinal Chemistry
|
| 2009-08 |
Synaptic Scaffolding Molecule Binds to and Regulates Vasoactive Intestinal Polypeptide Type-1 Receptor in Epithelial Cells |
Gastroenterology
|
| 2009-08 |
The role of translation elongation factor eEF1A in intracellular alkalinization-induced tumor cell growth |
Laboratory Investigation
|
| 2009-06 |
In Situ Measurement of Airway Surface Liquid [K+] Using a Ratioable K+-sensitive Fluorescent Dye |
Journal of Biological Chemistry
|
| 2008-11 |
PAR2 exerts local protection against acute pancreatitis via modulation of MAP kinase and MAP kinase phosphatase signaling |
American Journal Of Physiology-Gastrointestinal And Liver Physiology
|
| 2008-07 |
Heterogeneity in the processing defect of SLC26A4 mutants |
Journal Of Medical Genetics
|
| 2008-06 |
Cell-based fluorescence screen for K(+) channels and transporters using an extracellular triazacryptand-based K(+) sensor |
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
|
| 2008-05 |
alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity |
Journal Of Pharmacology And Experimental Therapeutics
|
| 2008-03 |
Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel |
Molecular Pharmacology
|
| 2007-06 |
Interleukin-1 beta upregulates Na+-K+-2Cl(-) cotransporter in human middle ear epithelia |
JOURNAL OF CELLULAR BIOCHEMISTRY
|
| 2007-04 |
Pharmacodynamic characteristics and cardioprotective effects of new NHE1 inhibitors |
EUROPEAN JOURNAL OF PHARMACOLOGY
|
| 2007-01 |
Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors |
JOURNAL OF BIOLOGICAL CHEMISTRY
|
| 2007-01 |
Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct |
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
|